This island 185 mi/300 km northeast of Portland is best known as the summer home of former U.S. President Franklin D. Roosevelt. It's actually a part of New Brunswick, Canada, but the Roosevelt International Park is controlled and administered by a joint Canadian-U.S. commission. The park preserves the estate and the red cottage where Roosevelt relaxed and recuperated. The beautiful little sanctuary is a nice place to spend a few hours (http://www.fdr.net). Also on Campobello is Herring Cove Provincial Park, with campsites, a golf course, a lodge, a beach and hiking trails.
Just south of Campobello, back in Maine, is Quoddy Head State Park, which sits on the easternmost point of land in the U.S. The candy-striped West Quoddy Head Light, built in 1807, is the highlight of the park and can be reached by four different walking trails. (http://www.westquoddy.com). Also worth seeing is Cobscook Bay State Park (near Edmunds), an area known for its widely fluctuating tides. Amateur naturalists will have a great time at Moosehorn National Wildlife Refuge. It's a wildlife and migratory-bird refuge consisting of two units, one near Edmunds, the other 20 mi/32 km to the north (http://www.fws.gov/northeast/moosehorn).
Before leaving the area, drive around Cobscook Bay to Eastport (http://www.eastport-me.gov), a quiet seaport town full of buildings that date to the early 1800s. Leave time for a quick tour of Raye's Mustard Mill (http://www.rayesmustard.com), an authentic stone mill that once produced mustard for the town's sardine packers. Today, Raye's produces gourmet mustards (tastings available).