The main U.S. Post Office is open 24 hours (and is known to have a line of customers at all hours of the day). Try to avoid the rush 5-7 pm. Some special services, including registered and certified mail, are offered only until midnight. Cutoff time for express-mail next-day delivery depends on destination. You must deposit regular mail by 7 pm for same-day postmark. The other U.S. Post Offices, scattered throughout the city, are open Monday-Friday 9 am-5:30 pm and are easily accessible. Some branches may have Saturday hours. The government-issue blue mailboxes, including boxes for express mail, stand at many intersections, especially in Midtown Manhattan. The main post office covers an entire block, across the street from Madison Square Garden-Penn Station. 441 Eighth Ave., at 33rd Street (subway line 1, 2, 3, A, C or E to 34th Street), New York City. Phone 212-330-3002. Toll-free 800-275-8777. http://www.usps.gov.