Granted, the notion of the Romantische Strasse was simply a marketing scheme, but it was a good one. Some of the prettiest towns in Germany are scattered along the route, a fact that millions of tourists discover every year.
The route stretches from Wurzburg in the north to Fussen in the south. North to south, follow highways E70, 290, 25, 2 and 17—not the A7 autobahn. These roads pass through Tauberbischofsheim (a medieval town), Bad Mergentheim (home to a spa), Weikersheim (a former palace), Rottingen, Rothenburg, Feuchtwangen, Dinkelsbuhl, Nordlingen (with perfectly preserved medieval walls), Harburg (with an impressive castle), Augsburg and Schongau. Take at least three days to see this area, spending time anywhere that appeals to you.